2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N1431A
    Tabersonine hydrochloride 29479-00-3 98.55%
    Tabersonine hydrochloride is a selective, orally active NLRP3 inhibitor. Tabersonine hydrochloride directly binds to the NACHT domain of NLRP3, inhibiting its ATPase activity and oligomerization, thereby blocking ASC spot formation and caspase-1 activation, and reducing the release of pro-inflammatory cytokines such as IL-1β. Tabersonine hydrochloride also inhibits K63-linked ubiquitination of TRAF6, blocking NF-κB, PI3K/Akt, and p38 MAPK signaling pathways. Tabersonine hydrochloride can inhibit inflammatory responses, induce apoptosis of liver cancer cells through mitochondrial pathways and death receptor pathways, reduce mitochondrial membrane potential, promote cytochrome c release, and activate caspase proteins. Tabersonine hydrochloride is mainly used in the study of NLRP3-driven inflammatory diseases (such as acute lung injury, sepsis, peritonitis) and tumors such as liver cancer.
    Tabersonine hydrochloride
  • HY-N14405
    Phenazostatin A 185614-22-6 98%
    Phenazostatin A is a phenazine Substance that has the protective effect of new neuron cells. Phenazostatin A can scavenge free radicals, protect N18-RE 105 nerve cells from glutamate toxicity, and inhibit lipid peroxidation. Phenazostatin A inhibits glutamate toxicity in N18-RE-105 cells with an EC50 of 0.34 μg/mL.
    Phenazostatin A
  • HY-N14406
    Phenazostatin B 73649-05-5 98%
    Phenazostatin B is a phenazine Substance that has the protective effect of new neuron cells. Phenazostatin B can scavenge free radicals, protect N18-RE 105 nerve cells from glutamate toxicity, and inhibit lipid peroxidation. Phenazostatin B inhibits glutamate toxicity in N18-RE-105 cells with an EC50 of 0.33 μg/mL.
    Phenazostatin B
  • HY-N14407
    Phenazostatin C 248939-29-9 98%
    Phenazostatin C can protect N18-RE-105 nerve cells from glutamate toxicity with an EC50 of 0.37 μM and inhibit lipid peroxidation. Phenazostatin C has low toxicity, and 100 μM of Phenazostatin C is not cytotoxic.
    Phenazostatin C
  • HY-N14417
    Indocarbazostatin 253450-08-7 98%
    Indocarbazostatin against Neurite outgrowth induced by NGF is 6 nM in rat pheochromocytoma PC12 cells.
    Indocarbazostatin
  • HY-N14424
    Indocarbazostatin B 334831-87-7 98%
    Indocarbazostatin B against Neurite outgrowth induced by NGF is 24 nM in rat pheochromocytoma PC12 cells.
    Indocarbazostatin B
  • HY-N14558
    3',8-Dihydroxy-4',6,7-trimethoxyisoflavone 57800-11-0 98%
    3',8-Dihydroxy-4',6,7-trimethoxyisoflavone is found in the strain of Streptomyces sp. 3',8-Dihydroxy-4',6,7-trimethoxyisoflavone is a catechole-O-methyltransferase inhibitor (IC50 is 0.2 g/mL).
    3',8-Dihydroxy-4',6,7-trimethoxyisoflavone
  • HY-N14662
    Griseolic acid B 98890-01-8 98%
    Griseolic acid B (7′-Desoxygriseolic acid) has the activity of inhibiting cyclic adenosine monophosphate (cAMP) phosphodiesterase [EC 3.1.4.17] with an IC50 of 0.16 μM.
    Griseolic acid B
  • HY-N1469R
    Kaurenoic acid (Standard) 6730-83-2
    Kaurenoic acid (Standard) is the analytical standard of Kaurenoic acid. This product is intended for research and analytical applications. Kaurenoic acid is a diterpene from Sphagneticola trilobata, inhibits Inflammatory Pain by the inhibition of cytokine production and activation of the NO–cyclic GMP–PKG–ATP-sensitive potassium channel signaling pathway.
    Kaurenoic acid (Standard)
  • HY-N1475R
    Nicotiflorin (Standard) 17650-84-9
    Nicotiflorin (Standard) is the analytical standard of Nicotiflorin. This product is intended for research and analytical applications. Nicotiflorin is a flavonoid glycoside extracted from a traditional Chinese medicine Carthamus tinctorius. Nicotiflorin shows potent antiglycation activity and neuroprotection effects.
    Nicotiflorin (Standard)
  • HY-N1478R
    Gardenoside (Standard) 24512-62-7 98%
    Gardenoside is an orally active natural compound found in Gardenia fruits. Gardenoside reliefs chronic constriction injury (CCI)-induced neuropathic pain by regulating the P2X3 and P2X7 receptors. Gardenoside has an inhibitory effect on free fatty acids (FFA)-induced cellular steatosis. Gardenoside reduces reactive oxygen species (ROS). Gardenoside can be used for anti-inflammatory, antinociceptive and hepatoprotective study.
    Gardenoside (Standard)
  • HY-N14827
    Xanthofulvin 151466-15-8 98%
    Xanthofulvin (SM-216289) is an inhibitor of semaphorin 3A. Xanthofulvin blocks its binding to receptors, inhibits growth cone collapse, and accelerates olfactory nerve regeneration in rats in vivo. Xanthofulvin can be used in studies related to traumatic neuronal injury.
    Xanthofulvin
  • HY-N14868
    Neuroprotectin B 354986-38-2 98%
    Neuroprotectin B is a cyclopeptide. Neuroprotectin B has the function of protecting chicken brain neuron culture from excitatory toxicity induced by glutamate and red alginate.
    Neuroprotectin B
  • HY-N14931
    Aestivophoenin A 171864-91-8 98%
    Aestivophoenin A, a microbial metabolite, is a neuronal cell protecting substance.
    Aestivophoenin A
  • HY-N14953
    Formobactin 181417-64-1 98%
    Formobactin is a free radical scavenging and neuronal cell protecting substance.
    Formobactin
  • HY-N15001
    Gabaculine 59556-18-2 98%
    Gabaculine is an amino acid neurotoxin and blood-brain barrier-permeable GABA transaminase inhibitor, with an IC50 of 1 μM in beef and Pseudomonas ovalis. Gabaculine elevates endogenous synaptic and brain GABA levels and enhances GABA activity. Gabaculine induces sedation, hypothermia, loss of righting reflex, and prevents convulsions in mice. Gabaculine is applicable to research related to neurological disorders.
    Gabaculine
  • HY-N1500R
    Pulegone (Standard) 89-82-7 98%
    Pulegone (Standard) is the analytical standard of Pulegone (HY-N1500). This product is intended for research and analytical applications. Pulegone is a monoterpene ketone compound widely present in the essential oils of many plants. Pulegone can also be used as a bird repellent. Pulegone has multiple activities such as anti-inflammatory, antibacterial, antifungal, and anti-hyperalgesic effects. Pulegone is particularly effective against bacteria of the Salmonella species.
    Pulegone (Standard)
  • HY-N15147
    Panax saponin C 51542-56-4 98%
    Panax saponin C is a ginsenoside found in Ginseng with biological activities including regulatory effects on immunomodulation, protection functions in the central nervous and cardiovascular systems, anti-diabetic, anti-aging, anti-carcinogenic, anti-fatigue, anti-pyretic, anti-stress, boosting physical vitality, and promotion of DNA, RNA, and protein synthesis activities.
    Panax saponin C
  • HY-N15180
    Corynantheidine 23407-35-4 98%
    Corynantheidine ((-)-Corynantheidine) is a mu-opioid receptor (MOR) partial agonist that shows MOR-dependent analgesic effects in mice.
    Corynantheidine
  • HY-N15291
    Divinatorin A 611228-04-7 98%
    Divinatorin A is a diterpenoid extracted from Salvia divinorum. Divinatorin A has hallucinogenic properties.
    Divinatorin A
Cat. No. Product Name / Synonyms Application Reactivity